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Nanotechnology Now – Press Release: HKUMed creates new two-dimensional (2D) ultrasonography-responsive antibacterial nanosheets to effectively treat bone tissue infections


Home > Press Releases > HKUMed creates new ultrasonography-responsive two-dimensional (2D) antibacterial nanosheets to effectively treat bone tissue infections

HKUMed creates a new two-dimensional (2D) responsive antibacterial nanosheet to effectively treat bone tissue infections. University of Hong Kong CREDIT

Abstract:
A research team led by Professor Kelvin Yeung Wai-kwok from Department of Orthopedics and Traumatology, School of Clinical Medicine, LKS School of Medicine, University of Hong Kong (HKUMed) has devised a non-invasive and non-antibiotic technology to effectively reduce methicillin-resistant infections. Staphylococcus aureus (MRSA) on bone tissue. The new antibacterial nanosheets can release large amounts of reactive oxygen species (ROS) subject to ultrasound stimulation. By engulfing the neutrophil (NM) membrane, the nanosheets are able to actively capture MRSA bacteria residing in bone tissue and effectively remove 99.72% ± 0.03%. The results have been published in Advanced Materials

HKUMed creates a new two-dimensional (2D) responsive antibacterial nanosheet to effectively treat bone tissue infections

Hong Kong, China | Posted on March 24, 2023

Background
Bone infection, namely osteomyelitis, is an infection that occurs in the bone or bone marrow caused by bacteria, fungi, or other microorganisms. A common causative pathogenic organism is MRSA. Severe infection can put the patient at risk for amputation or even cause life-threatening sepsis. In clinical practice, treatment of bone tissue infections usually involves antibiotics and surgical debridement to remove infected bone or tissue. However, the overuse of antibiotics not only compromises the innate immune function of the host, but can also lead to the emergence of drug-resistant pathogens. Recently, phototherapy, whether photodynamic or photothermal therapy, has been applied as an antibiotic-free strategy to treat bacterial infections. However, conventional phototherapy is not able to treat deep tissue infections such as bone due to its limited penetration power. Therefore, alternative antibiotic-free strategies that harness the penetrating power of ultrasound into human tissue are considered.

Research methods and findings
The HKUMed research team has discovered a new two-dimensional (2D) sonosensitiser, namely Ti3C2-SD(Ti3+) nano-sheets. Compare with conventional sonosensitisers set in zero dimension, where ROS generation efficiency is limited. An innovative 2D sonosensitiser containing multiple planar catalytic sites can effectively generate large amounts of ROS when triggered by an ultrasound signal. Once decorated with neutrophil membranes (NM), the NM-Ti3C2-SD(Ti3+) nanosheets (NM-nano-sheets) can actively track MRSA bacteria in bone tissue subject to ultrasound stimulation. In animal models, the new nanosheets eliminated MRSA bacteria in bone by more than 99.72%, whereas antibiotic therapy (Vanco) was ineffective. In addition, NM-nano-sheets can also relieve tissue inflammation and help bone repair after bone tissue infection can be controlled. Moreover, the NM-coated nanosheets do not present any acute biosafety concerns.

Research significance
Professor Kelvin Yeung Wai-kwok, commented, ‘Our design has reached a qualitative leap where the ROS catalytic site in the sonosensitiser has changed from zero-dimensional to two-dimensional. This invention can greatly increase the production of bactericidal (ROS). We may also consider applying these findings to postoperative bacterial infections commonly seen in bone cancer patients or patients with cystitis and peritonitis in the future.’

About the research team
This research study was led by Professor Kelvin Yeung Wai-kwok, Department of Orthopedics and Traumatology, School of Clinical Medicine, HKUMed. Dr Mao Congyang, postdoctoral fellow, is the first author. Professor Yeung’s team’s research interests include spinal deformities, orthopedic biomaterials, musculoskeletal tissue engineering, 3D bio-printing, and anti-bacterial nanomaterials.

Thank You
This work was jointly supported by National Key R&D Programs of China (R&D#2018YFA0703100), General Research Fund of Hong Kong Research Grant Council (Nos. 17214516 and 17207719), Hong Kong Health and Medical Research Fund (Nos.19180712, 20190422 and 21200592) , Innovation and Technology Fund Partnership Research Program (#PRP/030/30FX), National Science Fund for Outstanding Young Scholars (No. 51925104), Shenzhen Science and Technology Fund (No. JCYJ20210324120012034 and JCYJ20210324120009026), and Shenzhen Sanming Project of Medicine – ‘Team of Excellence in Spinal Disabilities and Degenerative Spinal Diseases’ (SZSM201612055).

Media inquiries
Please contact the University of Hong Kong School of Medicine LKS by email

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Contact:
Jaymee Ng
Hong Kong University

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