Review the article on asymmetric synthesis using arynes

Arynes, a synthetic intermediate in which a portion of the benzene ring is a triple bond, has been applied in various transformations of organic molecules and has long been of the interest of chemists as a very useful compound. In addition, with the advancement of aryne chemistry, the development of the arynes “asymmetric synthesis” reaction, which is expected to increase the synthesis efficiency of compounds with complex steric structures and facilitate the formation of new compounds, has attracted increasing attention.

However, asymmetric synthesis based on arynes, which is highly reactive and unstable, presents several challenges. Therefore, an asymmetric reaction that can realize high stereoselectivity of arynes needs to be developed.

Ken Kamikawa, Professor at the Graduate School of Science, Osaka Metropolitan University, published a review article on various asymmetric reactions based on arynes, arranged by style, and detailing their outlines and characteristics. Problems and unresolved prospects in this area are also described.

“Asymmetric synthesis using arynes is an unexplored field with many possibilities,” says Professor Kamikawa. “In the future, many researchers will enter this field, and their expertise and creativity will greatly expand the potential of asymmetric synthesis for developing drugs and materials.”

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