Repopulation of cancer cells after therapy: what is the mechanism?
“Targeted approaches to prevent post-therapy repopulation of cancer cells must be uncovered to prevent tumor recurrence and thereby increase the overall survival of this devastating disease.”
“Targeted approaches to prevent post-therapy repopulation of cancer cells must be uncovered to prevent tumor recurrence and thereby increase the overall survival of this devastating disease.”
BUFFALO, NY- June 23, 2023 – New research perspectives published in Oncoscience (Volume 10) on June 1, 2023 entitled, “Repopulation of cancer cells after therapy: what is the mechanism?”
The last two decades have brought about major advances in cancer treatment as patients with the disease are living longer lives with access to better diagnostic and therapeutic approaches. However, the disease remains incurable. One of the reasons for the high resistance of this disease is because cancer cells hide and escape from therapy, causing cancer recurrence. The process by which cells escape therapy is known as cancer cell repopulation.
Repopulation of cancer cells after therapy is a phenomenon that leads to treatment failure with consequent disease recurrence. The process is studied and the mechanism needs to be uncovered. In this new perspective, researchers Rewati Prakash And Carlos M. Telleria from McGill University And McGill University Medical Center discusses the problem of cancer cell repopulation after chemotherapy and radiotherapy.
Researchers are accumulating evidence suggesting that cancer cell repopulation may originate from therapy-resistant cancer stem cells, therapy-responsive cancer cells that become polyploid and then germinate into nearly diploid rapidly proliferating cells, and/or treatment-responsive cells undergo aging as a a temporary mechanism for survival, followed by cell cycle reinitiation.
“Perhaps a better approach to eliminating cancer cell repopulation is a combination treatment involving chemoradiation-induced transient senescence first, followed by senolytic therapy as recently discussed by Wang and colleagues (42).”
Continue reading: DOIs: https://doi.org/10.18632/oncoscience.577
Correspondence to: Carlos M. Telleria
Email: (email protected)
Keywords: cancer cell repopulation, cancer stem cells, polyploidy, neosis, transient aging
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DOI
10.18632/oncoscience.577
Research methods
Commentary / editorial
Research Subjects
Cell
Article title
Repopulation of Cancer Cells After Therapy: What is the Mechanism?
Article Publication Date
1-Jun-2023
